A post-doctoral fellow position is immediately available in Dr. Karen Bussardrsquo;s laboratory within the Department of Cancer Biology at Thomas Jefferson University, Sidney Kimmel Cancer Center, located in downtown Philadelphia. Dr. Bussard is looking for a highly motivated post-doctoral fellow interested in cancer metastasis to the bone and the tumor microenvironment. The laboratory utilizes murine models of metastasis, human patient samples, primary cell culture, molecular biology techniques, high-end fluorescence microscopy, biomedical engineering, and 3-D models to answer questions related to molecular and cellular aspects of bone metastatic breast cancer.

Recent work in the laboratory has identified a subpopulation of osteoblasts in the bone-tumor microenvironment that play a role in tumor progression. We are interested both in how this osteoblast subpopulation affects metastatic breast cancer cells as well as how these cells interact with the surrounding bone stroma during disease progression.

*Note: this is a grant funded position (Department of Defense).

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Candidates must have a Ph.D. in cancer biology, cell biology, molecular biology, or a closely related field. Candidates should also have authored at least one first author publication (either published or in revision) in reputable journals. Candidates will be working with cell-based models of cancer and murine models of cancer metastasis. Must be proficient in mouse handling/ experimentation, models of cancer, and performing molecular biology techniques including cloning/ plasmid manipulation, transfection, knock-in/knock-out experiments, real-time PCR, RT-PCR, immunoblotting, ELISA, microarray analysis, IHC/IF, standard cell culture, and fluorescence amp; confocal microscopy. Experience with 3D models of cell culture, exosomes, and/or a bioengineering background are also desirable.

Candidates should have excellent oral and written communication skills, highly developed interpersonal skills, and display initiative as well as independence.

Interested individuals must be authorized to work in the United States and should submit their CV (with publications as appropriate), a letter of interest, and the names and contact information of three (3) references with their application.

Jefferson Health delivers state of the art healthcare services to patients throughout the Delaware Valley and southern New Jersey. Jefferson (Philadelphia University + Thomas Jefferson University) provides more than 8,400 students from nearly 40 states and 40 countries with 21st century professional education. Combined, we have over 30,000 employees.

Jefferson Health, with 14 hospitals (seven are Magnet designated by the ANCC for nursing excellence) and 40+ outpatient and urgent care locations, offers a broad range of primary and complex, highly specialized care that touches the lives of more than four million patients annually. U.S. News amp; World Report has ranked Thomas Jefferson University Hospital among the nationrsquo;s best in eight specialties. Jefferson Health also includes the NCI designated Sidney Kimmel Cancer Center; it is one of only 70 such centers in the nation.

Thomas Jefferson University has ten colleges and three schools that offer more than 160 undergraduate and graduate programs. Our University is dedicated to inter-professional and transdisciplinary approaches to learning that offer a vibrant and expandable platform for professional education. Through this unique model, we are preparing our students for current and yet to be imagined careers.

As an employer, Jeffersonmaintains a commitment to provide equal access to employment. Jefferson values diversity and encourages applications from women, members of minority groups, LGBTQ individuals, disabled individuals, and veterans.