We are seeking highly motivated scientist to join the Pharmaceutical Development team at our Upper Providence site, in the suburbs of Philadelphia. In this position you will use your technical knowledge and abilities to implement process analytical technology (PAT) and associated data interpretation and modeling to generate process knowledge for primary (API) and secondary (drug product) that contributes to the development and deployment of state-of-the-art processes and technologies to enable delivery of our medicines.
Less than 30 miles from Philadelphia city center, our modern R&D hub at Upper Providence is built on 281 acres of gently rolling land and is home to over 3,000 of our R&D staff. This concentration of scientists provides a culture that inspires innovation, teamwork, and personal development while operating with transparency, respect and integrity.
At GSK we are committed to overcoming some of the biggest challenges in global health, delivering products of value in a responsible, sustainable way, and providing access to medicine for the world's poorest communities.
The environment is highly technical and dynamic as you will be collaborating across multi-disciplinary project teams. You will thrive in this environment if you are able to effectively prioritize and manage multiple tasks, communicate your recommendations clearly, and are a team player who enjoys working in diverse teams.
Success in this role will require practical process analysis and engineering skills, a curious, inquisitive nature, and a passion for working safely in the laboratory while developing innovative science and learning new skills. You will be working independently in the lab, with flexibility to plan and execute your own workload to deliver high quality results.
At GSK we are committed to growing with our talent, and we will provide you the tools to own and design your development plan and pursue a career trajectory in the areas that interest you the most. Working at GSK offers opportunity to broaden your experience across R&D and our medicine supply chain. GSK is a modern employer and offers flexible working hours and conditions (subject to approval of reasonable requests).
Process Engineering and Analytics delivers technical expertise to support the development of small molecule active pharmaceutical ingredient (API) and drug product manufacturing processes at GSK. Our scientists work with project teams to perform laboratory studies and support plant campaigns to ensure API and drug product of appropriate quality and quantity are produced. The key focus of this position will be to implement process analytical technology (PAT) and associated data interpretation and modeling to generate process knowledge API and drug product that contributes to the development and deployment of state-of-the-art processes and technologies to enable delivery of our medicines. The role is fast-paced and dynamic as you may be working on a number of multi-disciplinary teams.
This role will provide YOU the opportunity to contribute to analytical development and to progress YOUR career. Your responsibilities include some of the following...
Work safely, effectively and collaboratively on multi-disciplinary development teams including Chemists, Engineers, Analysts, Modelers and Material Scientists to deliver work packages required to understand API and drug product unit operations for effective scale-up
Learn and undertake setting up, operating and maintaining PAT equipment to collect process data for developing PAT methods (e.g. Mid IR, Raman, NIR, MS, HPLC, Particle Size, pH, conductivity, etc.)
Design and execute laboratory experiments for online trending of relevant process parameters in various unit operations with attention to safety. Interpret spectral and other analytical data. Develop and apply statistical and multivariate chemometric methods along with engineering and modeling principles as needed to analyze data. Document all work with high quality according to GSK policies and procedures.
Interpret experimental results and related information to generate clear process analytical knowledge that can be used to identify potential issues, facilitate optimization and control, and help provide solutions that ensure robust operation of API and drug product processes
Create and deliver effective technical presentations and written reports
Design and implement experimental plans to support new research directions and novel strategies to achieve project or department goals, such as rapid kinetic and crystallization modeling platforms.
We are looking for professionals with these required skills to achieve our goals:
BS in Chemical Engineering, Chemistry, or related pharmaceutical degree
If you have the following characteristics, it would be a plus:
1-3 years of industry experience in chemical or pharmaceutical manufacture
Experience with PAT, other analytical methods, pharmaceutical unit operations, and/or systems modeling
Previous contributions to multi-disciplinary pharmaceutical product development teams
Working knowledge of organic chemistry
Awareness of Quality by Design (QbD) principles and/or risk-based approaches to pharmaceutical development
Effective oral and written communication skills
Proven ability to troubleshoot and diagnose problems
Our values and expectations are at the heart of everything we do and form an important part of our culture. These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities:
Operating at pace and agile decision-making - using evidence and applying judgement to balance pace, rigour and risk.
Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution.
Continuously looking for opportunities to learn, build skills and share learning.
Sustaining energy and well-being.
Building strong relationships and collaboration, honest and open conversations.
Budgeting and cost-consciousness.
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GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class.
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